Small Caffeine Boost: ValuMeds headache medicine contains a small amount of caffeine to help supplement the effects of the pain reliever ingredients Acetaminophen and Aspirin. Large Family Size: Each bottle of our pain relief medicine contains 300 total caplets to help the entire family find long-lasting pain-free relief you can count on. Kick Migraines Fast: Our generic headache medicine can start providing relief in as little as 15 minutes, ideal for mild to severe sinus and tension headache relief. Total Pain Relief: This extra-strength headache medicine also helps relieve other aches and pains, such as arthritis, muscles aches, and menstrual cramps. Advanced Active Ingredients: Comparable to Excedrin Migraine Extra Strength tablets, the ValuMeds formula contains 250mg of Acetaminophen, 250mg of Aspirin, and 65mg of caffeine for reliable pain relief.