Vegan & Non-GMO - Manufactured without milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, corn and gluten. Produced in a facility that may process other ingredients with these allergens. Researched Nutritionals nervous system supplements & stress management supplements are professional-grade formulations. Supports Stress Management at Night - CalmMind is a proprietary blend that includes magnolia bark extract, valerian root, 5 HTP, turmeric extract, lemon balm extract, and an L-theanine supplement. Circadian PM also promotes normal cytokine function to relax the central nervous system.*. Supports Healthy Histamine Levels to Reduce Wakefulness - Includes HistaCalm blend to help reduce wakefulness by supporting healthy histamine levels in the brain. Promotes normal cytokine function to relax the central nervous system, leading to a healthy pain response.*. GABA Nervous System Support - Promotes a healthy central nervous system & initiation in falling asleep by increg GABA (gamma-aminobutyric acid), the primary inhibitory central nervous system neurotransmitter. This product's GABA supplement is in the form of premium PharmaGABA.*. Calming PM Formula - A multifaceted approach is needed to aid in falling asleep faster, staying asleep longer, and achieving higher quality rest. Circadian PM utilizes a blend of 10 ingredients, promoting multiple mechanisms of action to nurture healthy sleep and promote nighttime stress management.*.