Nitric Oxide Ultra (capsules) offers a blend of CranLoad and citrulline to support healthy blood flow by targeting nitric oxide production and flow-mediated dilation. The formula centers around CranLoad, a novel fruit blend developed as part of an extensive research proGram with the Institute of Nutrition and Functional Foods (INAF) and Université Laval in Quebec, Canada. CranLoad delivers a unique cranberry and grape seed blend that has been the subject of several trials. Cranberries and grapes are particularly generous sources of proanthocyanidins and other polyphenols. In addition to being powerful antioxidants, these compounds offer specific vascular support mechanisms that are associated with enhanced endothelial function. Research indicates that CranLoad provides statistically significant support for healthy flow-mediated dilation (FMD), an effect similar to arginine administration. FMD reflects blood vessel dilation mediated by nitric oxide synthase (NOS), an enzyme that generates the endogenous vasodilator, nitric oxide. In one study, the peak increase in brachial artery diameter following CranLoad supplementation was 2.8% at 60 minutes. A similar physiological effect has been demonstrated with arginine. Citrulline is included to support nitric oxide production in the blood vessel endothelium and other tissues. Research indicates that citrulline increases plasma arginine in a dose dependent manner and to a greater degree than arginine supplementation.