Did you know Prilosec OTCs Omeprazole can stop frequent heartburn before it begins With one Prilosec OTC Omeprazole 20mg pill each day, you can be free from frequent heartburn for 24 hours. Heartburn happens when stomach acid refluxes into the esophagus. Prilosec OTC is a proton pump inhibitor (PPI) that can block heartburn at the source, so you dont get heartburn in the first place. Prilosec OTCs delayed-release formula helps it pass through the tough stomach acid, turning down acid production. Some other heartburn relief treatments only neutralize the stomach acid and provide less relief (less than 24 hours), while Prilosec OTCs long lasting delayed-release formula can provide 24-hour frequent heartburn relief. Join more than 30 Million Americans and try Prilosec OTC - just 1 pill a day for 14 days and experience what zero heartburn feels like. Prilosec OTC is the #1 Doctor, Gastroenterologist and Pharmacist recommended frequent heartburn treatment for 15 straight years. Its possible while taking Prilosec OTC. Use as directed for 14 days to treat frequent heartburn. Do not take for more than 14 days or more often than every 4 months unless directed by a doctor. Not for immediate relief. P&G calculation based in part on Buying Households reported by the Nielsen Company through its Homescan Panel service in the US Market for Prilosec OTC for the period of 8/31/03 through 6/25/16. IQVIA ProVoice Survey, Jan 2005 Mar 2020.