SAMe is a metabolite of methionine (an essential amino acid). The formula provides 400 mg from 800 mg of SAMetosylate disulfate. The biologically active form of SAMe is the S,S structure. This formula is made naturally by fermentation and processed without chemical solvents to preserve 68-80% S,S SAMe, the highest active level available. SAMe supports the production of healthy connective tissue. Plus, SAMe metabolism supports the synthesis of glutathione, which is critical for antioxidant defenses and liver functions. SAMe methylation reactions are involved in the synthesis of phosphatidylcholine and neurotransmitters such as dopamine, norepinephrine, and serotonin, and has been shown to have a positive effect on mood. The formula is manufactured under low temperature and enteric-coated to ensure a biologically active product. JARROW FORMULAS SAM-E 400, 400MG, 30 TABLETS AT A GLANCE: * Contributes to the proper functioning of many biochemical systems * Ideal for those wanting to optimize cognitive function, mood, energy levels, liver activity and joint health* * Preserved bioavailability through low-temp and low-moisture manufacturing * Processed without solvents * Protected from degradation via enteric coating and blister-packaging SAM-e contributes to the proper functioning of many biochemical systems. S-adenosyl-L-methionine (SAM-e) is an amino acid derivative clinically documented to benefit brain, liver and joint function*. View larger. S-adenosyl-L-methionine (SAM-e) is an amino acid derivative clinically documented to benefit brain, liver and joint function.* Found in all living cells, SAM-e is called "activated methionine" and is formed via combination of ATP with methionine. Somewhat counterintuitively, however, methionine supplementation does not elevate SAM-e levels in the body. Rather, it elevates problematic homocysteine. SAM-e has undergone many clinical trials involving thousands of human subjects. Researchers have identified many structure- and function-based benefits of SAM-e involving over 40 biochemical processes. It is a biochemical workhorse with various diverse effects on the body, including improving liver function, supporting joint health and lifting mood.* LIVER DETOXIFICATION SAM-e metabolism supports glutathione (GSH) synthesis and glutathione-dependent enzymes, which support liver function.* GSH, the chief antioxidant and detoxifier inside cells, scavenges free radicals produced during carbohydrate breakdown for energy. Taurine is another end product of SAM-e metabolism. GSH and taurine are important for liver detoxification.* BRAIN FUNCTION SAM-e supports brain function by its methylation effects.* Methylation is the transfer of a methyl group (one carbon and three hydrogen atoms, CH3) from one molecule to another. SAM-e is the most important of all methyl-donors in mammalian metabolism. Donation of methyl groups supports numerous metabolic processes including brain function, energy production and DNA metabolism. Neurotransmitters, substances involved in nerve cell communication, are also products of methylation. These compounds include L-DOPA, dopamine, serotonin, epinephrine and phosphatidylcholine (in lecithin). SAM-e is thought to benefit cognitive health by supporting the production of such critical brain messengers.* In fact, many people report noticeable positive effects on brain and mood after only taking it for a short time.* ENERGY PRODUCTION Methylation from SAM-e is also critical for creatine production. Creatine metabolites are important for ADP to ATP recycling and storing energy for immediate needs. Supporting creatine levels may help maximize physical performance, reduce exercise fatigue and improve recovery after exercise.* LONGEVITY A healthy young body manufactures all the SAM-e it needs. However, with age, people are less able to produce adequate SAM-e. This may contribute to declining health on many levels. Fortunately, these disturbances are often boosted by SAM-e supplementation.* In addition, methylation of DNA is an important part of DNA repair. De-methylation of DNA contributes to the aging process. Proper methylation, via substances such as SAM-e, positively influences longevity.* HEALTHY CONNECTIVE TISSUE Research has shown that regular SAM-e supplementation helps support joint health, and is used regularly in Europe to promote joint mobility and comfort.* NOT ALL SAM-E IS CREATED EQUAL SAM-e exists in two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is inactive. Jarrow Formulas SAM-e is predominantly the active form. It is made naturally by microbiological fermentation and then specially processed, without solvents, to preserve 68-80 percent (S,S) SAM-e, the highest active level available. SAM-e is a highly reactive molecule and very fragile. It degrades rapidly under high heat or humidity. Improper handling of SAM-e can cause degradation in a matter of hours. Thus, the manufacturing process for Jarrow Formulas SAM-e is done under low temperature and low humidity, and the tablet is enteric coated and blister-packed. Pharmacokinetic studies show that oral supplementation of SAM-e is most effective when enteric-coated by special gastric fluid-resistant polymers, resulting in maximum blood levels.* NOTE: Side effects are rare and appear to be limited to gastrointestinal disturbances. This product complies with the proposed USP Monograph for SAM-e. WARNING: Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using. Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAM-e. ABOUT JARROW FORMULAS Jarrow Formulas' complete line of over 350 nutritional products includes vitamins, minerals, probiotics, standardized herbal concentrates, amino acids, enzymes and enteral nutrition products. Customers can be assured of purity, value and potency when choosing these products. WHAT'S IN THE BOX Jarrow Formulas SAM-e 400, 400mg, 30 Tablets. OTHER PRODUCTS FROM JARROW FORMULAS:

Superior Nutrition and Formulation: The goal of Jarrow Formulas is to promote optimal health with high-quality, effective, affordable, and superior formulation of dietary supplements; Our customers can be assured of purity, value, and potency. Enteric Coating: SAMe is a metabolite of methionine (an essential amino acid); This formula provides 400 mg from 800 mg of SAMetosylate disulfate and is manufactured under low temperature and enteric-coated to ensure a biologically active product. Brain Metabolism and Mood: SAMe methylation reactions are involved in the synthesis of phosphatidylcholine and neurotransmitters such as dopamine, norepinephrine, and serotonin; The formula has been shown to have a positive effect on mood. Joint Health, Liver Function and Antioxidant Defense: SAMe supports the production of healthy connective tissue; Plus, SAMe metabolism supports the synthesis of glutathione, which is critical for antioxidant defenses and liver functions. Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery. Highest Concentration of Active S,S Form: The biologically active form of SAMe is the S,S structure; The formula is made by fermentation and processed without chemical solvents to preserve 68-80 percent S,S SAMe, the highest active level available.

Best Sellers Rank: See Top 100 in Health & Household. Item Weight: 0.13 Pounds. Number of Items: 1. Unit Count: 30 Count. Age Range (Description): Adult. Special Ingredients: Amino Acid, Lecithin. Product Benefits: Joint Strength* Liver Detoxification* Mood and Brain Function*. Flavor: 400 MG. Diet Type: Vegetarian. Item Form: Tablet. Brand: Jarrow Formulas. : B0013OSJU0. Manufacturer: Jarrow Formulas. Date First Available: September 16, 2003. Item model number: P30525. Product Dimensions: 2 x 3 x 5 inches; 2.08 Ounces. Is Discontinued By Manufacturer: No.