Safe, notified to the Italian Ministry of Health and Made in Italy. You can take up to 2 tablets per day of Dinaven 500 according to your needs. Natural haemorrhoids treatment and circulation supplement. Diosmin and Hesperidin are two important bioflavonoids and extracts of Red Vine, Horse Chestnut and Butcher's Broom support their functions. Spider Veins and Varicose veins treatment: the diosmin and hesperidin, as well as helping with haemorrhoids, relieve problems such as varicose veins, fragile capillaries and restless legs. Rich in flavonoids as Diosmin (450 mg), Hesperidin (50 mg), Red Vine, Butcher's Broom and Horse Chestnut, it has a beneficial effect on microcirculation and capillary fragility. Blood Circulation supplement: Dinaven 500 is a dietary supplement which helps you with haemorrhoids, anal fissures, varicose veins and swollen nad heavy legs.