Comfort Zone Medicated Callus Removers - Comfort Zone's Medicated Callus Removers are an effective treatment to remove calluses on your feet and hands. The product consists of 8 medicated patches with maximum strength Salicylic Acid 40% to remove calluses, plus 12 protective pads to protect against pressure and friction. Directions: Wash affected area (you may soak callus in warm water for 5 minutes to assist in removal) and dry thoroughly. If necessary, cut medicated patch to fit callus. Cover medicated patch with pad. After 48 hours, remove medicated patch. Repeat procedure every 48 hours as needed for up to 14 days (until callus is removed). Do Not Use: If you are diabetic. If you have poor blood circulation. On irritated skin. On any area that is infected or reddened. Keep out of reach of children.