Comfort Zone Medicated Extra Thick Callus Removers Comfort Zone's Medicated Extra Thick Callus Removers are an effective treatment to remove calluses on your feet and hands. The product consists of 4 medicated patches with maximum strength Salicylic Acid 40% to remove calluses, plus 4 extra thick protective pads to protect against friction and reduce pressure. DIRECTIONS: First, wash affected area (you may soak the callus in warm water for 5 minutes to assist in removal) and dry thoroughly. If necessary, cut the medicated patch to fit callus. Next, carefully adhere the medicated patch directly over the callus. Cover medicated patch with pad. After 48 hours, remove the medicated patch. Repeat procedure every 48 hours as needed for up to 14 days (until callus is removed). DO NOT USE IF you are diabetic, you have poor blood circulation, on irritated skin, or on any area that is infected or reddened. Keep out of reach of children.