Senolytic Compounds (Cellular Senescence Reversal) Anthocyanins have been shown to display anti-SASP (senescence-associated secretory phenotype) properties. Healthy cells continually divide to replace old and damaged tissue. However, as we age, some cells stop dividing, which is known as "cellular senescence". These senescent cells damage the healthy cells around them, and this leads to a number of age-related diseases. Senolytic compounds, responsible for cellular senescence reversal, are critical components in healthy aging and cellular optimization. "Anti-senescence compounds: A potential nutraceutical approach to healthy aging", Ageing Research Reviews 46 (2018) 14–31 | Cytokine Reduction Purple corn extract has been shown to reduce pro-inflammatory cytokines, which are associated with numerous age-related diseases and systemic inflammation. "Purple corn extract induces long-lasting reprogramming and M2 phenotypic switch of adipose tissue macrophages in obese mice", Journal of Transitional Medicine, (2019) 17:237 | AMPK Activator Purple Corn Extract has been shown to increase AMP-activated protein kinase (AMPK). AMPK is a central regulator of energy homeostasis, which coordinates metabolic pathways and thus balances nutrient supply with energy demand. Because of the favorable physiological outcomes of AMPK activation on metabolism, AMPK has been considered to be an important therapeutic target for healthy aging. "Anti-diabetic effect of purple corn extract on C57BL/KsJ db/db mice", Nutrition Research and Practice 2015;9(1):22-29 and "AMPK activators: mechanisms of action and physiological activities", Experimental & Molecular Medicine, 2016, 48 | Sirtuin Activator Anthocyanins have been shown to increase Sirtuin-6 (SIRT6) activity, which may be the most important sirtuin for increased lifespan, DNA-repair, metabolism, and inflammatory response reduction. SIRT6, also known as the "longevity sirtuin", has been shown to help maintain NAD+ levels in our bodies as we age. Sirtuins are protein enzymes that regulate numerous cellular functions and are crucial components of cellular health. There are 7 different types of sirtuins (Sirtuin-1 to Sirtuin-7). "Natural polyphenols as sirtuin 6 modulators", Scientific Reports, 2018, 8:4163 and "Restoration of energy homeostasis by SIRT6 extends healthy lifespan", Nature Communications, 2021, 12:3208 |